Studies have shown that nobiletin can improve cognitive function and reduce the deposition of beta-amyloid in the brain, thereby alleviating the symptoms of Alzheimer’s disease. In addition, nobiletin can also activate signaling molecules related to neuronal extension, further enhancing its protective effect on cognitive function.
Reduce neuronal apoptosis
In animal models, nobiletin has been shown to reduce neuronal apoptosis and protect retinal ganglion cells (RGCs) from damage caused by hypoxia and increased intraocular pressure. For example, in a glaucoma model, nobiletin enhanced the resistance of neurons to cumulative damage by activating the Nrf2/HO-1 pathway.
Reduce neuroinflammation
Nobiletin can significantly reduce neuroinflammation and protect neurons from inflammatory damage by inhibiting the expression of inflammatory factors and reducing the activation of inflammatory cells. This anti-inflammatory effect is of great significance for the prevention and treatment of neurodegenerative diseases such as Parkinson’s disease.
Promote neuroregeneration
In addition to protecting existing neurons, nobiletin also has the potential to promote neuroregeneration. Studies have shown that nobiletin can activate the regenerative mechanism of neurons and promote the repair and regeneration of damaged neurons.
Summary
Nobiletin, as a natural polymethoxyflavonoid compound, shows great potential in the prevention and treatment of neurodegenerative diseases due to its significant antioxidant, anti-inflammatory and neuroprotective properties. Future studies will further explore its effects in clinical applications and provide new strategies for the treatment of neurodegenerative diseases.