Inhibit the production of inflammatory factors
It can significantly inhibit the secretion of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). By inhibiting the expression of these inflammatory factors, Nobiletin can effectively reduce the inflammatory response.
Regulate inflammatory signaling pathways
Nobiletin reduces the production of inflammatory factors by inhibiting the activation of the NF-κB signaling pathway. In addition, it can also reduce the inflammatory response by regulating the activation of the NLRP3 inflammasome.
Inhibit the activation of inflammatory cells
In the lipopolysaccharide (LPS)-induced mouse macrophage model, Nobiletin can significantly reduce the content of nitric oxide (NO) in the cell supernatant and inhibit the secretion of proinflammatory factors.
Regulate immune response
Nobiletin inhibits inflammatory response by regulating the activity of immune cells. For example, it can inhibit the activation of the IL-23/IL-17 axis, thereby reducing inflammation.