Nobiletin has a significant inhibitory effect on a variety of tumor cells, and its anti-tumor mechanism mainly includes the following aspects:
Inhibit tumor cell proliferation: Nobiletin can inhibit tumor cell proliferation by regulating cell cycle-related proteins.
Induce cell apoptosis: By activating multiple signaling pathways (such as PI3K/Akt/mTOR pathway, endoplasmic reticulum stress, etc.), Nobiletin can induce tumor cell apoptosis.
Inhibit tumor cell migration and invasion: Nobiletin can reduce the migration and invasion ability of tumor cells by inhibiting related signaling pathways (such as ERK, JNK pathway) and the expression of matrix metalloproteinases (MMPs).
Combined with chemotherapy drugs to enhance the anti-tumor effect: When Nobiletin is used in combination with chemotherapy drugs, it can enhance the anti-tumor effect of chemotherapy drugs.