Mechanism of Action
Increase fat decomposition:Hesperidin Methylchalcone can increase the lipolysis of adipocytes, promote the decomposition and metabolism of fat, and thus reduce the deposition of lipids in the body.
Improve energy metabolism: Through increase the number of mitochondria, increase ATP levels and oxygen respiration consumption rate, thereby enhancing the body’s energy metabolism level and helping to consume more fat.
Regulate lipoprotein lipase activity: Hesperidin Methylchalcone may interact with lipoprotein lipase (LPL), increase the activity of LPL, and further promote the decomposition and metabolism of fat.
Research evidence
Cell experiment: In the Hep G2 human liver cancer cell, AML12 mouse liver cell and LMH chicken liver cancer cell models induced by oleic acid and palmitic acid, HMC treatment reduced intracellular fat accumulation, indicating that it has the effect of reducing lipid deposition.
Animal experiment: In the mouse model induced by a high-fat diet, HMC can reduce the level of fat deposition in mice and alleviate liver fatty degeneration. At the same time, HMC can also increase the number of mitochondria, increase ATP levels and oxygen respiration consumption rate, and enhance energy metabolism.
Other related effects
Antioxidative stress: Hesperidin Methylchalcone is able to enhance the activity of reductive glutathionease, reduce the level of reactive oxygen and malondialdehyde content, thereby reducing the level of oxidative stress induced by high fat.
Improving insulin sensitivity: It can well increase the body’s sugar intake, reduce sugar output, improve insulin sensitivity, and help improve the disorders of sugar metabolism and lipid metabolism.