{"id":1828,"date":"2025-04-25T21:00:00","date_gmt":"2025-04-25T13:00:00","guid":{"rendered":"https:\/\/citrimore.com\/?p=1828"},"modified":"2025-04-27T09:16:46","modified_gmt":"2025-04-27T01:16:46","slug":"pharmacological-activities-of-luteolin","status":"publish","type":"post","link":"https:\/\/citrimore.com\/?p=1828","title":{"rendered":"Pharmacological Activities of Luteolin"},"content":{"rendered":"Luteolin has multiple pharmacological activities, and plants rich in luteolin are often used as traditional Chinese medicine to treat diseases. With the in-depth study of luteolin, it was found that it has anti-tumor effects such as inhibiting tumor cell proliferation, inducing tumor cell apoptosis, and sensitizing the activity of anticancer drugs. It also has anti-inflammatory, antioxidant and protective effects on the nervous system.<br \/><br \/>Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor 2 and interleukin 6 inhibitor. It can significantly reverse xylazine\/ketamine-induced anesthesia in mice. 4 Preclinical studies have shown that luteolin may have pharmacological effects, including antioxidant, anti-inflammatory, antibacterial and anti-cancer. Preliminary studies have found that luteolin can inhibit angiogenesis-induced apoptosis, affect the development of tumors in animal models, reduce tumor growth rate, and increase the cytotoxicity of certain anticancer drugs to tumor cells, indicating that luteolin may be a potential cancer chemoprevention drug and chemotherapy drug.<br \/><br \/>The mechanism of luteolin&#8217;s biological activity may be to regulate the level of ROS, inhibit topoisomerase I and topoisomerase II, reduce the activity of NF-\u03baB and AP-1 transcription factors, stabilize p53. and inhibit the activity of phosphoinositide 3-kinase, signal transducer and activator of transcription 3 (STAT3), insulin-like growth factor 1 receptor (IGF1R) and human epidermal growth factor receptor II.","protected":false},"excerpt":{"rendered":"<p>Luteolin has multiple pharmacological activities, and p [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1836,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1828","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"_links":{"self":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts\/1828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1828"}],"version-history":[{"count":1,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts\/1828\/revisions"}],"predecessor-version":[{"id":1834,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts\/1828\/revisions\/1834"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/media\/1836"}],"wp:attachment":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}