{"id":1815,"date":"2025-03-14T09:32:00","date_gmt":"2025-03-14T01:32:00","guid":{"rendered":"https:\/\/citrimore.com\/?p=1815"},"modified":"2025-03-13T16:34:33","modified_gmt":"2025-03-13T08:34:33","slug":"anti-inflammatory-effects-of-nobiletin","status":"publish","type":"post","link":"https:\/\/citrimore.com\/?p=1815","title":{"rendered":"Anti-inflammatory Effects of Nobiletin"},"content":{"rendered":"\n<p>Inhibit the production of inflammatory factors<\/p>\n\n\n\n<p>It&nbsp;can significantly inhibit the secretion of proinflammatory cytokines, such as tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6). By inhibiting the expression of these inflammatory factors, Nobiletin can effectively reduce the inflammatory response.<\/p>\n\n\n\n<p>Regulate inflammatory signaling pathways<\/p>\n\n\n\n<p>Nobiletin reduces the production of inflammatory factors by inhibiting the activation of the NF-\u03baB signaling pathway. In addition, it can also reduce the inflammatory response by regulating the activation of the NLRP3 inflammasome.<\/p>\n\n\n\n<p>Inhibit the activation of inflammatory cells<\/p>\n\n\n\n<p>In the lipopolysaccharide (LPS)-induced mouse macrophage model, Nobiletin can significantly reduce the content of nitric oxide (NO) in the cell supernatant and inhibit the secretion of proinflammatory factors.<\/p>\n\n\n\n<p>Regulate immune response<\/p>\n\n\n\n<p>Nobiletin inhibits inflammatory response by regulating the activity of immune cells. For example, it can inhibit the activation of the IL-23\/IL-17 axis, thereby reducing inflammation.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inhibit the production of inflammatory factors It&nbsp; [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1816,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1815","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"_links":{"self":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts\/1815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1815"}],"version-history":[{"count":1,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts\/1815\/revisions"}],"predecessor-version":[{"id":1817,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/posts\/1815\/revisions\/1817"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=\/wp\/v2\/media\/1816"}],"wp:attachment":[{"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citrimore.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}