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Citrus
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About Citrus

Citrus is a common term and genus of flowering plants in the family Rutaceae, originating in tropical and subtropical southeast Asia,China is one of important original centers. The word citrus is derived from the Ancient Greek kedros or its Latin derivate cedrus, names applied by the ancient Greeks and Romans to several different trees with fragrant foliage or wood (compare the completely unrelated cedars). The taxonomy and systematics of the genus are complex and the precise number of natural species is unclear, as many of the named species are clonally-propagated hybrids, and there is genetic evidence that even some wild, true-breeding species are of hybrid origin. Cultivated Citrus may be derived from as few as four ancestral species. Natural and cultivated origin hybrids include commercially important fruit such as the sweet oranges, grapefruit, lemons, limes (sour oranges) and tangerines.

Different citrus species contain different chemical ingredients or different content of ingredients.

1.Sour oranges (Citrus aurantium)
Sour orange contains hesperidin, neohesperidin, naringin, synephrine, N-methyltyramine. Immature fruit contains naringin, rhoifolin, lonicerin, neohesperidin. Neohesperidin disappears while fruit matures. The peel also contains nobiletin (5,6,7,8,3’,4’-hexamethoxy flavone),hesperidin,tangeritin (5,6,7,8, 4’-pentamethoxy flavone), 5,7,4’-trimethoxy flavone, sinensitin (5,6,7,3’,4’-pentamethoxy flavone), 5,7,8,4’-tetramethoxy flavone. The seed contains limonoids such as ichangin, deacetyl nomilin, limonin, nomilin, obacunone, deacetylnomilinic acid, isolimonic acid, nomilinic acid and their 17-β-D- glucoside, also contains  19-hydroxydeacetylnomilinic acid-17-β-D- glucoside.

2. Sweet oranges (Citrus sinensis)
Sweet orange contains naringenin-7-ruti-noside,that’s narirutin,isosaku-ranetin-7-rutinoside),eriocitrin,naringenin-4’-glucoside-7-rutinoside,synephrine,N-methyltyramine. The peel contains hesperidine,naringin,citrusin A,B,C, coniferin,syringin,dehydrodiconiferyl alcohol-4-β-D-glucoside,2”-O-β-xylosylvitexin,3-hydroxy-5,6,7,8,3’,4’-hexamethoxyflavone-3β-glucoside,that’s nobiletin-3-O-β-glucoside, 3,8-di-C-glucosylapigenin, 3,8-di-C-glucosyldiosmetin,trans-carveol-6β-glucopyranoside, a-terpineol-8-β-D-glucopyranoside, 9-hydroxylinalool-9-β-glucopyranoside, vomifoliol-9-O-β-D- glucopyranoside and narirutin so on. Also contains tangeritin, nobiletin, 5,7,4’-trimethoxy flavone, 5,7,3’4’-tetramethoxy flavone and 5,7,8,3’4’-pentamethoxy flavone, citrusin Ⅱ、Ⅲ、Ⅳ.

3. Citrus Reticulata 
Citrus Reticulata contains hesperidin,naringin,neohesperidin,poncirin,palmitic acid,stearoc acid,oleic acid,linoleic acid,linolenic acid,synephrine, N-methyltyramine. Immature fruit contains poncimarin,iso-poncimarin,7-geranyloxycoumarin(aurapten),6-methyoxyaurapten,bergapten, imperatorin. The seed contains isopimpinellin,prangenin(heraclenin),prangeninhydrate, bergapten, imperatorin, aurapten,6-methyoxyaurapten and limonoids such as limonin, deacetyl nomilin, ichangin, deacetyl nomilinic acid and isolimonic acid.

4.Peels of citrus fruits
Of course, the peels of fruit also contain a-pinene, β-pinene, myrcene, limonene, camphene, γ-terpinene, p-cymene, caryophyllene, linalool and so on.

Seven following disease categories had a statistically significant number of areas for reported uses of citrus ingredients: (1) diseases of the blood and blood-forming organs;(2) diseases of the musculoskeletal system and connective tissue;(3) diseases of the respiratory system;(4) diseases of the endocrine systems;(5) nutritional, metabolic diseases and immunity disorders;(6) infectious and parasitic diseases;(7) injury and poisoning; symptoms, signs, and ill-defined conditions.

 

Recent research has focused on the biological activity of compounds found in citrus species, including compounds called flavanoids, carotenoids and limonoids, especially in terms of their effects on citrus palatability and anti-cancer activity.

 

Citrus flavonoids have potential antioxidant (prevents aging), anti-cancer, antiviral, anti-inflammatory activities, effects on capillarity, and cholesterol-lowering ability. The principal carotenoids in pink grapefruit are lycopene and beta-carotene. Lycopene-containing fruits and vegetables have been shown to contribute to a significant reduction in prostate and mammary cancer risk.Recent studies have further shown that limonoids inhibit the development of cancer in laboratory animals and in human breast cancer cells as well as reducing cholesterol.


And essential oil from citrus peels are largely used in food industry as a flavor and fragrance.

DIOSMIN

DESCRIPTION

 

Diosmin is a semisynthetic flavonoid molecule derived from citrus d (modified hesperidin).

 

Diosmin is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage) in the eye or gums. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery,and to protect against liver toxicity. It is ofen taken in combination with hesperidin.

 

Diosmin is currently a prescription medication, and is also sold as a nutritional supplement.

 

 

TECHNOLOGY ADVANTAGES

 

High Assay: ≥95% for EP standard

 

Impurity Control: Total impurities ≤4.0%

 

Low Pesticide Residue

CAS No.: 520-27-4

 

EIENCS : 208-289-7

 

Molecular Formula: C28H32015

 

Molecular Weight: 608.545

 

Specification: EP, BP, USP, 90:10, Micronized

 

Appearance:

Greyish-yellow or light yellow hygroscopic powder.

 

Chemical Structure:

 

We can also control the qualityon customers' request.

DIOSMIN+HESPERDIN 90:10

It is the mixture of Diosmin and Hesperidin, which is widely used for pharmaceutical and food supplement.


NEW TECHNOLOGY

Benepure has developed new technology to get the mixture directly by reaction process instead of blending. And the assay can be customized as request.


SPECIFICATIONS


Micronized
Micronized+Granuated

diosmin001

HESPERIDIN

The flavonoid hesperidin is a flavanone glycoside (glucoside)
comprised of the flavanone (a class of flavonoids) hesperitin and the disaccharide rutinose. Flavonoids are a type of polyphenol, which are antioxidants found in plants and are essential to human health.


Besides its antioxidant properties, hesperidin can also be used as an anti-inflammatory,anti-allergic, hypolipidemic, vasoprotective, and anti-carcinogenic compound. It seems to reduce the symptoms of allergies and hay fever by inhibiting histamine production in the blood Hesperidin, in combination with a flavone glycoside called diosmin, is used for the treatment of venous insufficiency and hemorrhoids.

CAS No. 520-26-3
Molecular Formula: C28H34015
Molecular Weight: 610.57
Specification: 90~95% HPLC, 98% UV, Micronized
Chemical Structure:

RAW MATERIAL BASES

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Raw material harvest time is about June to August
Benepure would visit the bases and evaluate to make the purchasing plan, and select properly to guarantee the stability and abundance of the raw material supplying.

Hesperidin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.

 

Although some studies indicate that hesperidin has antioxidant activity in vivo, others do not demonstrate antioxidant activity in vitro. The possible anti-inflammatory action of hesperidin is probably due to the possible anti-inflammatory action of its aglycone hesperetin. Hesperetin appears to interfere with the metabolism of arachidonic acid as well as with histamine release. Hesperetin appears to inhibit phospholipase A2, lipoxygenase and cyclo-oxygenase. There is evidence that hesperetin inhibits histamine release from mast cells, which would account for the possible anti-allergic activity of hesperidin.

 

Again, the possible hypolipidemic effect of hesperidin is probably due to hesperetin’s possible action in lipid lowering. Hesperetin may reduce plasma cholesterol levels by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, as well as acyl coenzyme A: cholesterol acytransferase (ACAT). Inhibition of these enzymes by hesperetin has been demonstrated in rats fed a high cholesterol diet.

 

The mechanism of hesperidin’s possible vasoprotective action is unclear. Animal studies have shown that hesperidin decreases microvascular permeability. Hesperidin, itself or via hesperetin, may protect endothelial cells from hypoxia by stimulating certain mitochondrial enzymes, such as succinate dehydrogenase.

 

The mechanism of hesperidin’s possible anticarcinogenic action is also unclear. One explanation may be the inhibition of polyamine synthesis. Inhibition of lipoxygenase and cyclo-oxygenase is another possibility.

The flavonoid hesperidin is a flavanone glycoside (glucoside) comprised of the flavanone (a class of flavonoids) hesperitin and the disaccharide rutinose. Hesperidin is the predominant flavonoid in lemons and oranges,. The peel and membranous parts of these fruits have the highest hesperidin concentrations,especially in immature little citrus fruits.Orange juice containing pulp is richer in the flavonoid than that without pulp. Sweet oranges (Citrus sinensis) and tangelos are the richest dietary sources of hesperidin. Hesperidin is classified as a citrus bioflavonoid.

 

Hesperidin, in combination with a flavone glycoside called diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids. Hesperidin, rutin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P.

 

Hesperidin is a solid substance with low solubility in water. It is, however, much more soluble in water than its aglycone hesperetin.

Hesperidin has demonstrated some ability to favorably affect lipids and to treat some vascular disorders in humans. Other claims made for hesperidin are based on in vitro and animal studies. These include claims that hesperidin is useful in cancer and immune disorders. There are also claims that hesperidin is an anti-allergen and anti-inflammatory agent based on results from animal experiments.

 

Hesperidin is present in nutritional supplements as vitamin C with bioflavonoids. Typical dose in these products is about 20 mg. Hesperidin is available in hesperidin-complex supplements. Doses for this type of supplement are usually 500 mg to 2 grams daily. In Europe, hesperidin is available for the management of venous insufficiency and hemorrhoids in a combination product with diosmin. A 500-mg dose of this combination product is comprised of 50 mg of hesperidin and 450 mg of diosmin. Dose for this mixed flavonoid product, for the above conditions, is 1 to 3 grams daily. Another flavonoid, hesperidin methyl chalcone, is often marketed in formulations with hesperidin. This is a different flavonoid, and very few studies have been performed using it.

Commercial Hesperidin is obtained by extraction from immature citrus fruit.

HESPERIDIN METHYLCHALCONE

CAS No.:24292-52-2
Molecular Formula: C29H36015
Molecular Weight:624.59
Specification: 98% UV
Appearance: Yellow powder
Chemical Structure:

Hesperidin Methylchalcone is a methylate compound of soluble flavanone and soluble dihydrochalcone which can increase the effect of vitamin C with the same function as vitamin P.

 

What’s more, characters in strong anti-virus and anti-bacteria. It is Preventing influenza virus’ breeding with large dosage, inhibiting tyrosinase which causing skin to black.

 

For the treatment of black spot, freckle such skin disease. It has an effect on remaining normal permeability, boosting resistance, enhancing elastic and toughness of vessels, preventing and curing blooding of capillary or gums.

NARINGIN

CAS No.:10236-47-2
Molecular Formula: C27H32014
Molecular Weight: 580.54
Specification: 90%, 95%, 98% HPLC
Appearance: Almost white powder
Chemical Structure:

Naringin is a natural chemical compound known as a bioflavanoid found in grapefruit and other citrus fruits, giving it its bitter flavor.


Hence, the food industry, uses naringin as a bitter in “tonic” beverages, bitter chocolate, ice cream, and ices.


This bioflavonoid has antioxidant and antifungal properties, as such
may heIp prevent cancer and atherosclerosis (hardening of arteries), as well as a number of other ailments,such as Herpes, Diabetes, Alcoholism, Heart failure, Chronic venous insufficiency, Bruising.


Naringin also works synergistically with other nutrients, increasing the bio-availability (how much nutrient is absorbed by the body) and therefore maximizing the health benefits of these nutrients.

Naringin is a flavonoid extracted from grapefruit and other citrus fruits (albeit in lower amounts). Its content is up to 8% in some kinds of grapefruit in China when it is immature, but in some varieties, the content is nearly zero.


In Spain, University of Murcia reported that the distribution of the flavanones naringin and neohesperidin has been analyzed during the development of the leaves, flower buds, and fruits of Citrus aurantium. These flavonoids are at maximum concentration in the organs studied during the logarithmic phase of growth, gradually decreasing until the organs reach maximum development. However, this decrease in the naringin and neohesperidin concentration in leaves, flower buds, and fruits is due to a dilution of the flavonoids caused by cell growth, because total content per organ continues to increase. The levels of neohesperidin are always greater than those of naringin, although the ratio between the relative concentrations is different in the three organs studied. Leaves have the highest ratios, varying between 8.83 and 5.18, followed by flowers (3.15-1.85), and fruits (2.23-1.02). These observations suggest different relationships between the respective enzymic activities in their biosynthetic pathway.

Naringin belongs to a group of chemicals called bioflavonoids, which are colorful pigments found in plants. They were discovered by Nobel Prize-winning biochemist Albert Szent-Gyorgi, who labeled them “vitamin P” (although they were subsequently stripped of their vitamin status). Bioflavonoids belong to a larger group of phytochemicals called polyphenols. Key polyphenols include phenolic acids, flavonoids, stilbenes, and lignans. Flavonoids are the most abundant polyphenols in our diets.

Naringin is a natural chemical compound known as a bioflavanoid found in grapefruit, giving it its bitter flavor. Hence,the food industry, however, uses naringin as a bitter in “tonic” beverages, bitter chocolate, ice cream, and ices.


This bioflavonoid has antioxidant and antifungal properties, and as such may help prevent cancer and atherosclerosis (hardening of arteries), as well as a number of other ailments,such as Herpes ,Diabetes,Alcoholism,  Heart failure, Chronic venous insufficiency,Bruising.


Naringin also works synergistically with other nutrients, increasing the bio-availability (how much nutrient is absorbed by the body) and therefore maximizing the health benefits of these nutrients.


Of course,it is important to note this citrus extract interferes with enzyme activity in the intestines, and therefore can inhibit the breakdown of certain drugs. That is why you should consult with your physician if you are on any medication before eating grapefruit.

Commercial Naringin is obtained by extraction from immature fruit of Citrus Grandis Osbeck.

NEOHESPERIDIN

CAS No.: 13241-33-3
Molecular Formula: C28H34O15
Molecular Weight: 610.56
Specification: 95% HPLC
Appearance: Light white fine powder
Chemical Structure:

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It is the 7-0-neohesperidose derivative of hesperetin which in turn is the 4′-methoxy derivative of eriodictyol. 

 

The main use of Neohesperidin is to get Neohesperidin dihydrochalcone which is an intensive sweetener widely used in food and feed industry.

In Spain, University of Murcia reported that the distribution of the flavanones naringin and neohesperidin has been analyzed during the development of the leaves, flower buds, and fruits of Citrus aurantium. These flavonoids are at maximum concentration in the organs studied during the logarithmic phase of growth, gradually decreasing until the organs reach maximum development. However, this decrease in the naringin and neohesperidin concentration in leaves, flower buds, and fruits is due to a dilution of the flavonoids caused by cell growth, because total content per organ continues to increase. The levels of neohesperidin are always greater than those of naringin, although the ratio between the relative concentrations is different in the three organs studied. Leaves have the highest ratios, varying between 8.83 and 5.18, followed by flowers (3.15-1.85), and fruits (2.23-1.02). These observations suggest different relationships between the respective enzymic activities in their biosynthetic pathway.

 

Another interesting fact is that the level of naringin increases with the growth of citrus fruit while the level of neohesperidin decreases till disappears. In China it is reported that the level of Neohesperidine is the highest in the peel of immature Citrus aurantium.

Neohesperidin is a bitter,white to almost white powder. Melting poins at 236~237℃. It is easily soluble in hot water,hot ethanol,insoluble in ether.

The main use of Neohesperidin is to get Neohesperidin dihydrochalcone which is an intensive sweetener widely used in food and feed industry.

Commercial neohesperidin is obtained by extraction from immature citrus fruit.

HIDROSMIN

CAS No.: 115960-14-0
Molecular Formula:C30H36016
Molecular Weight: 654.6142
Specification: ≥85% HPLC
Appearance: Yellow or yellow-brown hygroscopic powder, odorless
Chemical Structure:

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Hidrosmin, a derivative of Diosmin , is a semisynthetic drug and a member of the flavonoid family. It is used for the treatment of venous diseases.

 

Compared with Diosmin, Hidrosmin is more effective, which can efficiently treats edema and varicose ulcer. Hidrosmin gains better water solubility, and can be more easily absorbed by human body, less dosage required when people take it.

HESPERETIN

CAS No. 520-33-2
Molecular Formula: C16H1406
Molecular Weight: 302.28
Specification: 90%, 95%, 98% HPLC
Appearanee:
Light-crearn yellow fine powder,melting point 226 228°, easily soluble in ethanol, soluble in diluted alkali solution, party soluble in diethyl ether, slightly soluble in water, chloroform and benzene.
Chemical Structure:

Hesperetin is the 4′-methoxy derivative of eriodictyol, a flavanone. Hesperetins 7-O-glycoside, is hesperidin. It is obtained from the enzymolyis of hesperidin.

It is mainly coming from the enzymolysis of hesperidin with the functions of invigorating the stomach,eliminating phlegm, Preventing cough, expelling rheumatism, treating diuresis, anti virus, anti microbial, treating non return and relieving stomachache, widely used in the food, pharmaceutical and healthcar poduct industry etc.

CITRUS AURANTIUM EXTRACT

SYNEPHRINE

CAS No.: 94-07-5
Molecular Formula: C9H13NO2
Molecular Weight: 167.21
Specification: 6%~98% HPLC
Appearanee: Brown to white fine powder
Chemical Structure:

Synephrine is the main active ingredient in the citrus aurantium extract, whichis mainly used in dietary supplements and slimming products. It can effectively oxidize fat and suppress appetite as the main component of slimming products.


Synephrine for the treatment of bronchial asthma and surgery and anesthesia, hypotension, collapse and shock, orthostatic hypotension. Synephrine is also a 21st centurynatural stimulant with no side effects and positive reactions.


It is widely used in the health care industries such as medicine, food and beverage. The demand and value of synephrine will increase with the ban on the use of chemicallysynthesized drugs.

Synephrine is an alkaloid (a pharmacologically active class of nitrogen-containing chemical compounds). Its chemical structure is similar to ephedrine, the primary active alkaloid in ephedra, aka ma-huang. There are only two chemical differences between ephedrine and synephrine: in synephrine one of the ring carbons is hydroxylated (a hydroxyl group {OH} replaces a hydrogen atom {H} ), and a side chain methyl group (CH3; Me) is replaced by hydrogen.

 

Therefore,synephrine is a stimulant, similar to caffeine and ephedrine, it is thought to have similar effects in terms of providing an energy boost, suppressing appetite and increasing metabolic rate and caloric expenditure

Synephrine is only rarely used as a drug in China, sometimes in high doses to treat shock, similar to the use of high doses of ephedrine for emergency cases of asthma. It is given by intravenous drip or push, with a dose of 20-60 mg. Using chi-shi aqueous extract in injection form, the dose used in Chinese medical practice corresponded to 20-60 grams of the herb, which could contain 60-180 mg of synephrine (3). These doses of the citrus alkaloids are similar, on a milligram basis, to those of ephedrine. Similarities in chemical structure, dosage, and effects between synephrine and ephedrine suggest that they may be compared directly. Synephrine was also suggested in Chinese and Western medical literature to be a potential treatment for bronchial asthma, as is ephedrine. 


In USA, Citrus aurantium Extract with different levels of syenphrine is largely used in various products of weight loss and dietary supplements, and it can be used in beverage in EU countries although there are some disputes about its side effect.

Synephrine is found mainly in the medicinal products derived from bitter orange. Bitter orange also called Seville orange, is known botanically as Citrus Aurantium L. This ingredient appears to be present in slightly higher quantities in the unripe fruit than in the ripe fruit.

 

Some citrus materials that have been assayed in China have a higher synephrine content; in one study, synephrine levels in citrus fruits and peels ranged from as little 0.1% to a very high 2.0% (9), while most reports place the level at about 0.25%.

Commercial synephrine (Citrus Aurantium Extract) is obtained by extraction from immature fruits of Citrus Aurantium L.

CITRUS BIOFLAVONOIDS

Specification: 20%-85% HPLC, Water Soluble 10%-35%
Appearance:
Brownish powder,soluble in dimethyl formamide and formamide at 60°, slightly soluble in methanol and heat glacial acetic acid, practically insoluble in acetone, benzene and chloroform, freely soluble in dilute alkali and pyridine.
Chemical Structure:

The common citrus bioflavonoids include Apigenin, D1osmin, Diosmetin, Hesperidin,Hesperetin, Naringin, Naringenin, Narirutin, Neohesperidin, Nobiletin, Quercetin,Rutin, Tangeretin.

 

Citrus bioflavonoids and related substances are widely used to treat diseases of the blood vessels and lymph system, including hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising, nosebleeds, and lymphedema following breast cancer surgery.

 

Citrus bioflavors are thought to work by strengthening the walls of blood vessels.

 

Citrus bioflavonoids are believed to have antioxidants, anti viral, anti-inflammatory,and anti-allergy properties. They have been shown to help fight infection, free radical damage, viruses and the common cold.

Bioflavonoids are a group of plant pigments that are responsible for the colors of many flowers and fruits. Citrus bioflavonoids are the bioflavonoids found in citrus fruits. The common citrus bioflavonoids include Apigenin,Diosmin,Diosmetin, Esperidin, Hesperidin, Hesperitin, Naringin, Naringenin, Narirutin, Neohesperidin,Nobiletin,Quercetin,Rutin,Tangeretin,Tangeritin.


The subgroup of flavonoids that possess biological activity (“bio” is a Greek prefix that indicates a relationship to life).

Citrus bioflavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylated flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions. These biological properties are consistent with their effects on the microvascular endothelial tissue. Evidence suggests that the biological actions of the citrus flavonoids are possibly linked to their interactions with key regulatory enzymes involved in cell activation and receptor binding.


One of the main actions of citrus bioflavonoids is their work as antioxidants. Antioxidants function in the body to eliminate free radicals. Free radicals are incomplete molecules which result from normal body processes like breathing as well as exposure to environmental conditions like pollution, cigarette smoke, sunlight or herbicides. Free radicals cause damage on the cellular level and, if left unchecked, can lead to premature aging and are thought to contribute to the development of certain degenerative diseases.

The efficacy of flavonoids and flavonoid-rich extracts in treating varicose veins is related to their ability to: (1) reduce capillary fragility, (2) increase the integrity of the venous wall, (3) inhibit the breakdown of the compounds composing the ground substance, and (4) increase the muscular tone of the vein.


Citrus bioflavonoids and related substances are widely used in Europe to treat diseases of the blood vessels and lymph system, including hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising, nosebleeds, and lymphedema following breast cancer surgery. Citrus bioflavonoids are thought to work by strengthening the walls of blood vessels.


Citrus bioflavonoids are believed to have anti-viral, anti-inflammatory, and anti-allergy properties. They have been shown to help fight infection, free radical damage, viruses and the common cold.


Citrus bioflavonoids are essential for the effective utilization of Vitamin C by the body. Bioflavonoids slow down the normal breakdown of Vitamin C in the body allowing it to be more effective. There is a mutual relationship between Vitamin C and citrus bioflavonoids as they work to mutually enhance the action of each other.

Natural Citrus bioflavonoids are obtained directly from peel of citrus fruits or unripe little Citrus fruits. Then the main ingredients from different citrus species,such as Lemon, Grapefruit, Orange or Mandarine are total different. The main Citrus bioflavonoid obtained from little orange is Hesperidine which is almost insoluble in water, but from grapefruit the main bioflavonids are naringin and Neohesperidin which are soluble in water.

Commercial Citrus bioflavonoids complex is obtained by extraction from different citrus fruits.

About Citrus

Benepure is a global research, manufacture and supplier of ingredients and their derivatives for healthcare industry. It owns strong research and development team, cutting-edge equipment, high-standard manufacturing base and philosophy of professional service, devoted to offering new products and innovative services in varied fields of pharmaceutical, functional food, cosmetics and feed industries. Our objective: we strive to provide high-standard products and professional services with higher efficiency and more convenience . we’ll never stop trying for humans’ health.

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